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Abstract #3744

The association between the 1H-MR spectroscopy biomarker of astrogliosis and the PET biomarker of microglia in the thalamus in multiple sclerosis

Firat Kara1, Nur Neyal2, Mike G. Kamykowski1, Christopher G. Schwarz1, June Kendall-Thomas2, Holly A. Morrison3, Matt L. Senjem1, Scott A. Przybelski3, Angela J. Fought3, John D. Port3, Dinesh K. Deelchand4, Val J. Lowe3, Gulin Oz4, Kejal Kantarci1, Orhun Kantarci3, and Burcu Zeydan1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Radiology, Mayo Clinic, Rochster, MN, United States, 3Mayo Clinic, Rochester, MN, United States, 4University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, magnetic resonance spectroscopy, ER176 TSPO PET, Thalamus

Motivation: Thalamic innate immune activation in multiple sclerosis (MS) is implicated in neurodegeneration and thalamic atrophy, and potentially accelerating functional decline. Understanding its drivers could aid in developing targeted interventions.

Goal(s): To investigate the links between thalamic innate immune activation and thalamic atrophy, using multimodal imaging metrics to explore innate immune activation and neurodegenerative mechanisms in patients with MS.

Approach: We investigated associations among 1H-MRS, ER176-TSPO-PET biomarkers, and thalamic volume in patients with MS patients and non-MS controls.

Results: In patients with MS, higher mIns/tCr correlated with higher ER176-TSPO-PET SUVR and lower thalamic volume, supporting multimodal imaging for assessing underlying disease processes in MS.

Impact: This study demonstrates the utility of combining MRS, PET, and MRI to explore innate immune activation and neurodegeneration in multiple sclerosis, potentially guiding targeted interventions by offering a comprehensive view of thalamic involvement in disease development and progression.

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