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Abstract #3749

REMYELINATION AND ITS ASSOCIATION WITH OXYGEN EXTRACTION FRACTION DIFFER BETWEEN MALE AND FEMALE IN MULTIPLE SCLEROSIS

Praveena Elanghovan1, Thanh Nguyen2, Shun Zhang2, Yi Wang2, Susan A. Gauthier3, and Junghun Cho2
1Department of Biomedical Engineering, The State University of New York at Buffalo, Buffalo, NY, United States, 2Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 3Department of Neurology, Weill Cornell Medicine, New York, NY, United States

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, Oxygenation, oxygen extraction fraction, quantitative susceptibility mapping, quantitative blood oxygen level dependent imaging, QSM, qBOLD, QSM+qBOLD, QQ

Motivation: Remyelination in multiple sclerosis (MS) is associated with restoring brain function. Understanding its mechanism is therefore essential for developing effective treatment strategies, yet it remains understudied.

Goal(s): To investigate the relationship between early stage remyelination and oxygen extraction fraction (OEF) and to compare this relationship between male and female.

Approach: Using a novel MRI-based OEF mapping technique, QQ, we processed longitudinal MRI scans at baseline, 3 months, and 12 months in 22 MS patients (9 male and 13 female).

Results: In female, OEF and myelin increased from baseline to 3 months, with changes positively associated, whereas male showed no such increases and associations.

Impact: This study demonstrates QQ’s feasibility for investigating the relationship between remyelination and OEF and its differences between male and female in MS. QQ-based OEF mapping can help develop gender-tailored therapeutic interventions for remyelination.

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Keywords