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Abstract #3755

Quantifying longitudinal tract profile differences in multiple sclerosis lesional tracts

Adrian Wu1, Anthony Traboulsee2, David K.B. Li3, Roger Tam3, Jiwon Oh4, Irene Vavasour3,5, Poljanka Johnson2, Neale Wiley1, Erin Gallinger2, Alex MacKay1,3, Shannon Kolind1,2,3,5, and Sharada Balaji1
1Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, 3Radiology, University of British Columbia, Vancouver, BC, Canada, 4Medicine (Neurology), University of Toronto, Toronto, ON, Canada, 5International Collaboration on Repair Discoveries, Vancouver, BC, Canada

Synopsis

Keywords: Multiple Sclerosis, Data Analysis

Motivation: Region-of-interest analyses of quantitative MRI measures may overlook heterogeneity in tissue microstructure. Tract profiling shows greater detail but is difficult to quantify over time.

Goal(s): Quantify differences in lesional tract profiles across two timepoints.

Approach: Tract profiles associated with focal lesions of myelin water fraction (MWF) and fractional anisotropy (FA) were created in people with multiple sclerosis (MS) who were scanned at two timepoints twelve months apart. Two measures were proposed to quantify tract profile differences, and were correlated with expanded disability status scale (EDSS) scores.

Results: The mean absolute difference in MWF between two timepoints along lesional MS tracts correlated with EDSS.

Impact: Differences in lesional tract profiles of myelin water fraction and fractional anisotropy were quantified across two timepoints twelve months apart using two newly proposed measures in people with multiple sclerosis, and showed moderate correlations with clinical scores.

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