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Abstract #3759

Simultaneous T2 and T2* Mapping in Multiple Sclerosis using Accelerated 2in1-RARE-EPI and Model-Based Reconstruction

Jose Raul Velasquez Vides1,2, Thomas Gladytz1, Jason M. Millward1, Sonia Waiczies1, Shahriar Shalikar1, Joseph Kuchling3,4,5, Friedemann Paul3,4,5, Lisa Krenz1, Georg Rose2,6, and Thoralf Niendorf1,3
1Berlin Ultrahigh Field Facility (B.U.F.F), Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2Institute for Medical Engineering, Otto von Guericke University, Magdeburg, Germany, 3Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 4NeuroCure Clinical Research Center, Charité--Universitätsmedizin, Berlin, Germany, 5Department of Neurology, Charité-Universitätsmedizin, Berlin, Germany, 6Research Campus STIMULATE, Otto von Guericke University, Magdeburg, Germany

Synopsis

Keywords: Multiple Sclerosis, Quantitative Imaging

Motivation: Quantitative MRI (qMRI) offers enhanced sensitivity to subtle brain tissue alterations but is limited by long acquisition times.

Goal(s): To advance 2in1-RARE-EPI for faster, simultaneous T2 and T2* mapping in Multiple sclerosis patients, minimizing artifacts and improving image quality.

Approach: 2in1-RARE-EPI was combined with advanced model-based reconstructions, with a tiny golden angle k-space trajectory, and an external shimming tool for T2, T2*, and PD mapping. Initial maps for the EPI reconstruction were obtained from the RARE solution.

Results: Phantom and in vivo studies showed good correlation between 2in1-RARE-EPI and reference methods, reduced noise in T2* maps, and clear lesion detection in MS patients.

Impact: 2in1-RARE-EPI combined with model-based reconstruction methods provides a technical foundation supporting clinical qMRI of neuroinflammatory and neurodegenerative diseases. It also has the potential for accelerated and simultaneous T2 and T2* mapping of the myocardium, eyes, and kidneys.

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Abstract

Keywords