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Abstract #3772

Investigation of multiparametric exchange protons using CEST and Z-spectrum analysis proton (ZAP) in human brain

Hye Na Jung1,2, Vadim Malis2, Marin McDonald2, and Mitsue Miyazaki2
1Radiology, Korea Univeristy Guro Hospital, Seoul, Korea, Republic of, 2Radiology, University of California, San Diego, La Jolla, CA, United States

Synopsis

Keywords: Aging, Magnetization transfer, CEST & ZAP

Motivation: To investigate a combination of CEST and ZAP as multiparametric biomarkers of age-associated changes in the human brain.

Goal(s): To investigate and find biomarkers using CEST/ZAP in the brain.

Approach: Multiparametric macromolecular exchange proton CEST/ZAP measurements are investigated at clinical 3T. 2D SSFSE sequence is acquired using an MT pulse train with a B1,rms of 2 uT to cover ± 6 ppm for CEST and ± 100 ppm for ZAP.

Results: CEST yields presence of hydroxyl-, amino-, and amide protons, while ZAP offers restricted and free exchange protons and their fractions. CEST and ZAP demonstrate distinguished metrics in different parts of the brain.

Impact: Observing macromolecular exchange protons by CEST and ZAP may provide the presence of characteristic irregular tissues that are not possible to observe in regular MRI. This suggests a potential biomarker related to age-associated changes in the brain.

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Keywords