Meeting Banner
Abstract #3775

Brain arteriolosclerosis is linked to lower in-vivo cortical volume in community-based older adults.

Ana Tomash1, Md Tahmid Yasar1, Abdur Raquib Ridwan2, David A Bennett2, Julie A Schneider2, and Konstantinos Arfanakis1,2
1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, United States

Synopsis

Keywords: Aging, Blood vessels, Arteriolosclerosis, Brain, Pathology, In-vivo applications, Neurodegeneration, Vascular

Motivation: Arteriolosclerosis is a prevalent small vessel disease in older adults, yet its relationship with specific cortical and subcortical brain volumes remains underexplored in vivo.

Goal(s): To examine the association of brain arteriolosclerosis with subcortical and cortical volumes.

Approach: Volumetric analysis of subcortical and cortical regions using in-vivo MRI was integrated with detailed neuropathological assessments in a large number of community-based older adults who underwent autopsy.

Results: More severe brain arteriolosclerosis was associated with lower volume in the middle temporal gyrus, independent of the effects of other neuropathologies and demographics.

Impact: The finding that brain arteriolosclerosis is linked to a lower volume of the middle temporal gyrus deepens our comprehension of the brain abnormalities associated with this prevalent small vessel disease.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords