Keywords: Preclinical Image Analysis, Alzheimer's Disease, aging, PET, network analysis, amyloid, tau
Motivation: It is poorly known how amyloid-beta (Aβ) and tau accumulations associate at the spatiotemporal level in the brain to impact cognitive changes in older adults prior to Alzheimer's disease (AD).
Goal(s): This study aims to understand the spatiotemporal relationships between Aβ and tau topologies in the brain and the early cognitive changes in older adults.
Approach: We investigate cortical patterns of Aβ and tau accumulations using graph theory-based longitudinal positron emission tomography (PET) imaging analysis and examined their effects on cognitive scores.
Results: Spatiotemporal correlations between tau-to-tau and tau–Aβ accumulations are critical players in the emergence of cognitive changes in the aging brain.
Impact: Our findings support using graph theory-based spatiotemporal analysis between Aβ and tau accumulations as an imaging marker for preclinical AD and have implications to understand the complex role of Aβ–tau interactions on cognitive decline prior to development of AD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords