Abstract #3786

Pre- and Post-operative Regional Fetal Brain Growth in Fetuses with Spina Bifida Aperta

Kelly Payette¹, Raimund Kottke², Patrice Grehten², Luca Mazzone^3,4, Martin Meuli^4,5, Beatrix Latal^5,6,7, Nicole Ochsenbein-Kölble^4,5,8, Beth Padden^6,9, Ueli Moehrlen^4,5,6,10, and Andras Jakab^1,11

¹Center for MR-Research, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland, ²Department of Diagnostic Imaging, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland, ³Department of Pediatric Surgery, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁴The Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland, ⁵University of Zurich, Zurich, Switzerland, ⁶Zurich Center for Spina Bifida, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁷Child Development Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁸Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland, ⁹Division of Pediatric Rehabilitation, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland, ¹⁰Department of Pediatric Surgery, University Children’s Hospital Zurich, University of Zurich, Zurich, Switzerland, ¹¹Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland

Synopsis

Keywords: Fetal, Fetal, Spina Bifida

Motivation: It is important to understand fetal brain development in fetuses impacted by spina bifida aperta to aid in prenatal planning.

Goal(s): We aim to identify imaging biomarkers that can potentially aid in the decision-making process for in utero spinal lesion closure surgery and discover the impact of disease characteristics on regional fetal brain growth.

Approach: Pre- and post-operative fetal brain MRIs were acquired, and regional fetal brain growth pre- and post-operatively were compared to lesion type and Chiari II hindbrain herniation level in 96 patients.

Results: Relationships between the cerebellum, brainstem and eCSF volumes were found with lesion type and hindbrain herniation level.

Impact: Longitudinal fetal brain MRI of spina bifida patients has the potential to expand our knowledge of fetal brain development in neural tube disorders.

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