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Abstract #3789

From Fetal to Neonatal: Divergent Trajectories of Human Brain Iron Development Across Regions Revealed by Whole-Brain R2* Assessment

Lanxin Ji1, Bosi Chen1, Iris Menu2, Christopher Trentacosta3, and Moriah Thomason1
1New York University School of Medicine, New York, NY, United States, 2Paris Cité University, Paris, France, 3Wayne State University, Detroit, MI, United States

Synopsis

Keywords: Fetal, Brain

Motivation: Sufficient iron is critical for early brain development, but the timing and sequence of brain iron changes from fetal to neonatal stages remain unclear.

Goal(s): We aim to map brain iron growth trajectories across birth and examine how sex, age at birth, and birth weight influence R2* development

Approach: Using a longitudinal multi-echo fMRI dataset, we estimated R2* in 88 regions and modeled growth from 25 to 55 post-conceptual weeks.

Results: Most parietal regions show near-linear trajectories, while occipital regions exhibit non-linear trends, with faster increases before birth. Certain regions in the frontal lobe and temporal lobe develop faster after birth.

Impact: These findings provide the first insights into R2* development across birth longitudinally, laying the foundation for future research into the neural mechanisms underlying iron deficiency-related developmental disturbances.

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