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Abstract #3794

Spatio-Temporal Ganglionic Eminence MRI Atlas

Tommaso Ciceri1,2, Andrea Righini3, Letizia Squarcina4, Adele Ferro5, Filippo Arrigoni3, Cecilia Parazzini3, Nicola Persico6, Simona Boito6, Irene Cetin6, Giorgio Conte7, Fabio Maria Triulzi8, Alessandra Bertoldo9, Paolo Brambilla10, and Denis Peruzzo1
1NeuroImaging Lab., IRCCS Eugenio Medea, Bosisio Parini (LC), Italy, 2University of Padua, Padova, Italy, 3Children’s Hospital V. Buzzi, Milano, Italy, 4University of Milan, Milano, Italy, 5Neurosciences and Mental Health, IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy, 6Department of Woman, Child and Newborn, IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy, 7IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy, 8Services and Preventive Medicine, IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy, 9University of Padua, Milano, Italy, 10Pathophysiology and Transplantation, University of Milan, Milano, Italy

Synopsis

Keywords: Fetal, Fetal, Ganglionic Eminence, Spatio-Temporal MRI Atlas, Segmentation

Motivation: Characterize Ganglionic Eminence (GE) development during pregnancy to better understand derailments from typical trajectory that can potentially play a role in future clinical conditions.

Goal(s): Construct a spatio-temporal MRI atlas of the GE during pregnancy.

Approach: We extended up to 19 weeks the T2w dHCP atlas, generating a label map of the GE from the segmentations performed by 3 expert neuroradiologists.

Results: The GE reached its maximum volume at 21-weeks, followed by a pronounced decrease throughout the pregnancy (R2 = 0.96). Neuroradiology experts show strong agreement in the segmentation task, achieving an average dice score of 0.91.

Impact: The spatio-temporal fetal MRI atlas of the GE allows researchers to study potential future clinical conditions attributable to GE alterations in pregnancy. The GE reached its maximum expansion at 21 weeks, followed by a pronounced reduction throughout the pregnancy.

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Keywords