Abstract #3796

Brain volumetry and T2* relaxometry in fetuses with Congenital Diaphragmatic Hernia

Charline Bradshaw^1,2, Jordina Aviles Verdera², Mary Rutherford², Megan Hall^1,2,3, Alena Uus², Anastasija Arechvo⁴, Mirjam Moser⁴, Kypros Nicolaides⁵, Jana Hutter^2,6, and Lisa Story^2,7

¹Women and Children's Health, King's College London, London, United Kingdom, ²Early Life Imaging Research Department, King's College London, London, United Kingdom, ³King's College London, London, United Kingdom, ⁴Fetal Medicine Research Institute, King's College NHS Foundation Trust, London, United Kingdom, ⁵Fetal Medicine Research Institute, King's College London, London, United Kingdom, ⁶Smart Imaging Lab, University Hospital Erlangen, Erlangen, Germany, ⁷Department of Women and Children's Health, King's College London, London, United Kingdom

Synopsis

Keywords: Prenatal, Brain

Motivation: Congenital Diaphragmatic Hernia (CDH) is a severe congenital anomaly associated not only with impaired pulmonary development but also neurodevelopmental sequelae. There is currently limited data regarding the extent to which alterations commence in the antenatal period.

Goal(s): To explore differences in brain development in a cohort of fetuses with and without CDH.

Approach: Comparisons between MRI derived regional brain volumes and supratentorial mean brain T2* measurements were made between CDH and control groups.

Results: A reduction in white matter, brain stem and cerebellar volumes was noted. No differences in mean T2* values were found.

Impact: This study has demonstrated that alterations in brain development have antenatal antecedents in fetuses with CDH. Further work is required to correlate these findings with longer term neurodevelopmental outcomes to aid prognostication and further management.

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