Abstract #3798

Negative Impacts of Germinal Matrix-ventricular Hemorrhage on Fetal Brain Development

Haoxiang Li¹, Yi Liao², Juncheng Zhu², Mingxuan Liu¹, Jialan Zheng³, Hongjia Yang¹, Zihan Li¹, Ziyu Li⁴, Qiyuan Tian^1,5, and Haibo Qu²

¹School of Biomedical Engineering, Tsinghua University, Beijing, China, ²Department of Radiology, West China Second University Hospital, Sichuan University, Chengdu, China, ³Tanwei College, Tsinghua University, Beijing, China, ⁴Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ⁵Tsinghua Laboratory of Brain and Intelligence, Tsinghua University, Beijing, China

Synopsis

Keywords: Fetal, Fetal, GVM-IVH

Motivation: Fetal GMH-IVH has varying degrees of impact on pregnancy outcomes, but its developmental impacts are still unclear.

Goal(s): To quantitatively investigate impacts of GMH-IVH on prenatal and postnatal brain development.

Approach: Imaging data from 42 fetuses with GMH-IVH were retrospectively used. Deep learning-enhanced image processing techniques were employed to quantify fetal brain morphological features, which were compared between abnormal and 1269 healthy fetuses across gestational weeks.

Results: Significant ventricular enlargement and notably smaller gray matter volume were identified in GMH-IVH fetuses, along with a markedly lower rate of white matter development in surviving infants compared to healthy controls.

Impact: This study used a large dataset to clarify the negative consequence of GMH-IVH on prenatal and postnatal brain development, which can lead to improved diagnosis, management strategies, and potentially better outcomes for affected fetuses and infants.

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