Keywords: Contrast Agents, Contrast Agents
Motivation: While manganese-based enhancement of MRI is an alternative to gadolinium-based considering NSF, the toxicity of contrast-origin free Mn2+ should also be mitigated; manganese-single-atom could be a novel candidate for contrast agents with approved maximized atom utilization structure.
Goal(s): Our goal was to investigate the performance of manganese-single-atom MRI enhancement both in vitro and in vivo.
Approach: After characterized structure, its contrast enhancement in vitro and mouse models of subcutaneous tumor and liver metastases were performed at 3.0T.
Results: With well-defined coordinate structure contrast, manganese-single-atom showed high r1 over 36mM-1s-1 in aqueous solution and contrasted to distinguish tumor from normal tissue, especially liver-targeted probe.
Impact: The first attempt to apply manganese-single-atom in MEMRI improves that the paramagnetic metal-single-atom is the novel and ideal candidate for MRI contrast agents with charming high performance, which expand its biomedical application beyond approved therapeutic functions.
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