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Abstract #3873

68Ga-NaGdF4-RGD nanoprobes for PET/MR Dual-Modal Imaging of cancer in Vivo

sitong wu1,2, wenyue li3, qi yang2, zhao chen2, yinghua zou2, yi hou3, and lei kang2
1China-Japan Friendship Hospital, beijing, China, 2Peking University First Hospital, beijing, China, 3Beijing University of Chemical Technology, beijing, China

Synopsis

Keywords: Contrast Agents, Contrast Agents, NaGdF4 nanoparticles, Tumor targeting peptide, Magnetic resonance imaging, Positron emission tomography, Multimodal imaging

Motivation: There are still rare multi-modality contrast agents or probes that can enhance both the signals of PET and MRI synchronously in clinical.

Goal(s): We developed a strategy of synchronous PET/MR diagnosis of tumor based on 68Ga-NaGdF4@RGD nanoprobes.

Approach: The in vivo PET/MR multimodal simultaneous imaging capability of 68Ga-NaGdF4-RGD nanoparticles was validated by a wider variety of tumor models. Additionally, the relationship between the targeting effect and integrin αvβ3 expression levels was explored.

Results: The fact suggested that 68Ga-NaGdF4-RGD probes possessed satisfying tumor-specific targeting ability . The level of enrichment of the nanoprobes was found to reflect the expression level of integrin αvβ3 in tumors.

Impact: This study successfully achieved simultaneous PET/MR multimodal imaging, which significantly improves the diagnostic accuracy of tumour. The radioactivity uptake of can reflect the integrin αvβ3 expression level of the tumour, and PET/MR is expected to be used for tumour staging.

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