Abstract #3876

MRI study of the optic nerve in the first whole eye and face transplant patient

Patryk Filipiak^1,2, Kamri Clarke^1,2, Alay Shah³, Sachin Chinta³, David L. Tran³, Zakia Ben Youss^1,2, Omnia Hassanin^1,2,4, Vaidehi S. Dedania⁵, Mary Bruno^1,2, Evan G. Stein^1,2, Yvonne W. Lui^1,2, Daniel J. Ceradini³, Eduardo D. Rodriguez³, and Steven H. Baete^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, NYU Langone Health, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, NYU Langone Health, New York, NY, United States, ³Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, United States, ⁴Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States, ⁵Department of Ophthalmology, NYU Langone Health, New York, NY, United States

Synopsis

Keywords: Microstructure, Tractography & Fibre Modelling, optic nerve, eye transplant

Motivation: 46-year-old male with catastrophic face injury and left globe loss received the first whole eye and face transplant. Our study targets postoperative changes to the affected Optic Nerve (ON).

Goal(s): We aimed to probe the neural structure and function of the ON with MRI.

Approach: Over 18 months, we acquired a series of diffusion and functional MRI. We then applied tissue microstructure modeling to monitor longitudinal changes along the ON.

Results: DTI and NODDI models identified optic neuropathy and axonal swelling. No functional connectivity from the transplanted globe to the visual cortex was confirmed.

Impact: This preliminary study demonstrates plausibility and reproducibility of probing postoperative changes to the transplanted ON noninvasively with MRI.

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