Abstract #3881

Multivariate white matter microstructure in coronary artery disease: links to aerobic fitness and cognition

Zacharie Potvin-Jutras^1,2,3, Stéfanie A. Tremblay^1,2,3, Dalia Sabra^1,2,4, Ali Rezaei^1,2,3, Safa Sanami^1,2,3, Christine Gagnon², Brittany Intzandt^5,6, Amélie Mainville-Berthiaume⁷, Lindsay N. Wright^1,2,3, Ilana R. Leppert⁸, Christine L. Tardif^8,9,10, Mathieu Gayda^2,11, Christopher J. Steele^3,7,12, Josep Iglesies-Grau^2,11, Anil Nigam^2,11, Louis Bherer^2,11,13, and Claudine J. Gauthier^1,2,3

¹Physics Department, Concordia University, Montreal, QC, Canada, ²Centre Epic and Research Center, Montreal Heart Institute, Montreal, QC, Canada, ³School of Health, Concordia University, Montreal, QC, Canada, ⁴Department of Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada, ⁵BrainLab, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada, ⁶Dr Sandra Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, ON, Canada, ⁷Department of Psychology, Concordia University, Montreal, QC, Canada, ⁸McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada, ⁹Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada, ¹⁰Department of Biomedical Engineering, McGill University, Montreal, QC, Canada, ¹¹Department of Medicine, Université de Montreal, Montreal, QC, Canada, ¹²Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ¹³Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada

Synopsis

Keywords: Microstructure, Microstructure, Multivariate approach

Motivation: Patients with coronary artery disease (CAD) are at an increased risk of cerebrovascular disease. Evidence regarding pathological alterations in white matter (WM) microstructure in patients with CAD is lacking.

Goal(s): This study assessed WM abnormalities in patients with CAD and their associations with cardiorespiratory fitness and cognition.

Approach: WM abnormalities were quantified using the Mahalanobis distance to measure deviation from a healthy reference group across 12 WM features.

Results: These findings suggest that higher WM abnormalities observed in patients with CAD may contribute to a heightened risk of cognitive impairment and that cardiorespiratory fitness may provide a protective effect on WM health.

Impact: Our findings indicate that higher white matter alterations in patients with coronary artery disease could increase the risk of cognitive deficits, while higher cardiorespiratory fitness may preserve white matter health, potentially aiding in the management of the disease.

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