Keywords: Microstructure, Cancer
Motivation: To overcome the challenge of low prostate DWI signal without the use of an endorectal coil (non-ERC), for implementation of hybrid multi-dimensional MRI (HM-MRI).
Goal(s): To demonstrate and validate non-ERC HM-MRI for non-invasive estimation of tissue compartment volume fractions (epithelium, stroma, and glandular lumen) and their use for lesion diagnostics.
Approach: An alternative TE/b-value sampling scheme was implemented and the resulting volume fraction estimates are compared to quantitative pathology data.
Results: Tissue compartment volume fractions were successfully calculated in 37 ROIs that were correlated with pathology. Excellent diagnostic performance was demonstrated.
Impact: A successful and validated implementation of hybrid multi-dimensional MRI (HM-MRI) without the use of an endorectal coil will lead to broader clinical application, resulting in better prostate MRI diagnostic performance and better predictive value of prostate MR-guided biopsy.
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