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Abstract #3886

Implementation of hybrid multi-dimensional MRI (HM-MRI) for non-endo-rectal coil prostate MR imaging

Milica Medved1,2, Aritrick Chatterjee1,2, Abel Lorente Campos1,2, Batuhan Gundogdu1,2, Sherry Huang3, Aytekin Oto1,2, and Gregory S Karczmar1,2
1Radiology, The University of Chicago, Chicago, IL, United States, 2Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy, The University of Chicago, Chicago, IL, United States, 3GE Healthcare, Royal Oak, MI, United States

Synopsis

Keywords: Microstructure, Cancer

Motivation: To overcome the challenge of low prostate DWI signal without the use of an endorectal coil (non-ERC), for implementation of hybrid multi-dimensional MRI (HM-MRI).

Goal(s): To demonstrate and validate non-ERC HM-MRI for non-invasive estimation of tissue compartment volume fractions (epithelium, stroma, and glandular lumen) and their use for lesion diagnostics.

Approach: An alternative TE/b-value sampling scheme was implemented and the resulting volume fraction estimates are compared to quantitative pathology data.

Results: Tissue compartment volume fractions were successfully calculated in 37 ROIs that were correlated with pathology. Excellent diagnostic performance was demonstrated.

Impact: A successful and validated implementation of hybrid multi-dimensional MRI (HM-MRI) without the use of an endorectal coil will lead to broader clinical application, resulting in better prostate MRI diagnostic performance and better predictive value of prostate MR-guided biopsy.

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