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Abstract #3890

Microstructural Imaging with a Nonlinear Gradient: Pushing the Limit of Short Diffusion Time

Horace Z. Zhang1, Els Fieremans2, Dmitry S. Novikov2, Albert J. Sinusas1,3,4, and Gigi Galiana1,4
1Department of Biomedical Engineering, Yale University, New Haven, CT, United States, 2Center for Biomedical Imaging, Department of Radiology, Grossman School of Medicine, New York University, New York, NY, United States, 3Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University, New Haven, CT, United States, 4Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States

Synopsis

Keywords: Microstructure, Microstructure, Gradient, Radial Diffusivity, Time-Dependent, Musculoskeletal

Motivation: Locally high gradient strength from a nonlinear gradient paves a new way for microstructure MRI at short diffusion times well below 10ms, and the geometry of the nonlinear gradient suits skeletal muscle of lower extremities.

Goal(s): To derive radial diffusivity of calf muscle at short diffusion times and derive the microstructure.

Approach: We designed a diffusion encoding scheme integrating linear and nonlinear gradients, and developed Radial Diffusivity Imaging. We estimate surface-to-volume ratio from the radial diffusivity at short diffusion times.

Results: With diffusion times as short as 4ms, the time-dependent radial diffusivity shows expected square-root time dependence, enabling quantification of calf muscle microstructure.

Impact: With the high strength of nonlinear gradient, this study reveals time-dependent diffusivity of the calf muscle at short diffusion times, and sheds light on microstructure of the calf muscle non-invasively.

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Keywords