Abstract #3897

Microstructural mapping based on time-dependent diffusion MRI for differentiating rectal neuroendocrine tumor and rectal adenocarcinoma

Yanwan Li¹, Xiaoli Chen¹, Xiaolei Dong¹, Siqi Yi¹, Meining Chen², and Peng Zhou¹

¹Department of Radiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China, ²MR Research Collaboration, Siemens Healthineers Ltd., Chengdu, China, Chengdu, China

Synopsis

Keywords: Microstructure, Diagnosis/Prediction, Neuroendocrine tumor, Time-dependent diffusion MRI

Motivation: Rectal neuroendocrine tumors, commonly mistaken for adenocarcinoma, are usually diagnosed invasively due to conventional MRI's limited microscopic detail. Advanced MRI techniques offer a non-invasive solution.

Goal(s): This study aims to investigate the feasibility of time-dependent diffusion MRI (td-dMRI) in differentiating between rectal neuroendocrine tumors and rectal adenocarcinoma.

Approach: The td-dMRI was used to analyze extracellular diffusivity (Dex), cell diameter (d), volume fraction (Vin), and cellularity to distinguish between rectal neuroendocrine tumors and rectal adenocarcinoma.

Results: The td-dMRI-derived parameters, particularly d and cellularity, effectively distinguished neuroendocrine tumors from adenocarcinoma, highlighting its potential for non-invasive histopathology.

Impact: Microstructural parameters derived from td-dMRI have the potential to serve as imaging biomarkers for the non-invasive differentiation of rectal neuroendocrine tumors, thus aiding in the prediction of histopathological types of rectal cancer.

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