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Abstract #3899

Double diffusion encoded MRI to identify Alzheimer’s disease pathology in postmortem brainstem by Diffusion Tensor Subspace Imaging (DiTSI)

Courtney J Comrie1, Victor Sandrin1, Laurel Dieckhaus1, Geidy Serrano2, Thomas G Beach2, Mark Bondi3, Seraphina Solders4, Vitaly Galinsky4, Lawrence R Frank4, and Elizabeth Hutchinson1
1Biomedical Engineering, University of Arizona, Tucson, AZ, United States, 2Banner Sun Health Research Institute, Sun City, AZ, United States, 3Department of Psychiatry, University of California San Diego, La Jolla, CA, United States, 4University of California San Diego, La Jolla, CA, United States

Synopsis

Keywords: Microstructure, Diffusion Acquisition, Double Diffusion Encoding

Motivation: Diffusion MRI may provide clinically relevant markers of degenerative pathology in Alzheimer’s disease if the specificity of the frameworks can be improved. Double diffusion encoding frameworks are promising for their improved selectivity.

Goal(s): Optimization of methods and initial description of alterations in postmortem brainstem imaging with diffusion MRI including single diffusion frameworks of DTI and MAP-MRI as well as the DDE DiTSI framework.

Approach: High-resolution, high-quality diffusion MRI scans over a comprehensive encoding range were used to map metric in healthy and AD pathologic brain stem tissue

Results: Four anisotropy metrics across the three frameworks were different in contrast and alteration with pathology.

Impact: If double diffusion encoding MRI can be optimized for the detection of specific pathology in Alzheimer's disease and other brain disorders, a new class of improved imaging markers may be possible.

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Keywords