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Abstract #3901

Correlation Tensor MRI of the Mouse Brain at 3 Tesla

Rafael Neto Henriques1, Andrada Ianus2, Noam Shemesh1, and Rui V. Simões3
1Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal, 2Imaging Physics and Engineering Research Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 3Institute for Research & Innovation in Health (i3S), University of Porto, Porto, Portugal

Synopsis

Keywords: Microstructure, Diffusion Modeling

Motivation: Correlation Tensor MRI (CTI) is a novel diffusion MRI technique that captures unique microstructural properties without relying on conventional tissue assumptions. However, its initial development on high-field preclinical scanners limits the direct translatability of preclinical findings to the clinical field-strengths used in human systems, and thus, to patient applications.

Goal(s): To evaluate CTI's feasibility on a 3T preclinical scanner.

Approach: CTI was implemented on a 3T preclinical scanner and tested on in vitro water phantoms, as well as in ex vivo and in vivo mouse brain imaging.

Results: CTI demonstrated reliability on the 3T preclinical scanner, delivering results consistent with prior high-field measurements.

Impact: This study reports the first implementation of Correlation Tensor MRI (CTI) on a 3T preclinical MRI scanner. This could facilitate the translation of CTI’s microstructural insights in animal models of human disease to clinical applications in patients.

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