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Abstract #3907

Utilizing Diffusion Models to Evaluate Brain Glymphatic Function Through Perivascular Space Enlargement Analysis

Chao-Hsin Michael Ding1, Chih-Chin Heather Hsu1, Shin Tai Chong1, Chun-Yi Zac Lo2, and Ching-Po Lin1,3
1Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan, 2Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan, Taiwan, 3Department of Education and Research, Taipei City Hospital, Taipei, Taiwan

Synopsis

Keywords: Diffusion Modeling, Neurofluids

Motivation: This study uses a non-invasive diffusion model to evaluate the mechanism of glymphatic dysfunction linked to PVS enlargement.

Goal(s): First, investigate the relationship between glymphatic function, enlarged PVS volume fraction, and age; second, evaluate glymphatic function's mediation and moderation in age-related changes of PVS volume.

Approach: T1w images map PVS areas, divided into white matter (WM) and subcortical regions, to analyze fluid signal fraction (from high b-value DWI) and pseudo-diffusion axial diffusivity (from low b-value DWI) within the PVS.

Results: Age-related changes in PVS and glymphatic function were observed only in the WM area, where fluid amount acts as moderator

Impact: These findings enhance our understanding of the brain's glymphatic system and guide future research into its mechanisms, emphasizing the importance of considering regional differences in glymphatic function's role in PVS changes.

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