Abstract #3909

Tensor-Valued Diffusion MRI Assessment of Acute Spinal Cord Injury in Rats

Jianyu Yuan¹, Kun Wang², Mingyao Liang³, Xing Yang^1,4,5, Hai Lu², and Yi He^1,4

¹Paul C Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Department of Spine Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China, ³The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China, ⁴National Innovation Center for Advanced Medical Devices, Shenzhen, China, ⁵University of Chinese Academy of Sciences, Beijing, China

Synopsis

Keywords: Microstructure, Spinal Cord

Motivation: There is an urgent need to achieve a more profound comprehension of the intricate processes of neural plasticity associated with acute spinal cord injury (ASCI).

Goal(s): To explore whether advanced tensor-valued diffusion MRI (dMRI) can yield sensitive microstructural readouts and evaluate acute injury in spinal cord.

Approach: We performed advanced tensor-valued diffusion MRI in ASCI rats and examined the sensitivity and specificity of the metrics.

Results: The tensor-valued dMRI metric, microscopic fractional anisotropy (µFA), serves as a more sensitive marker for identifying damaged fibers and gray matter in injured spinal cords.

Impact: Tensor-valued diffusion MRI is a promising neuroimaging tool to evaluate microstructural alteration in ASCI, especially in gray matter, helping characterize different microstructural features of acutely injured SC for precision medicine.

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