Abstract #3914

Cross-site comparison of IVIM parameters from the feet of patients with diabetic foot ulcers (DFU).

Scott Jameson Edwards^1,2, Jesica Flores^3,4, Gabriel Santamarina^4,5,6, Marcos Schechter^4,7, Maya Fayfman^4,5, and David Reiter^1,8,9

¹Biomedical Engineering, Emory University, Atlanta, GA, United States, ²Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, United States, ³Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States, ⁴Grady Memorial Hospital, Atlanta, GA, United States, ⁵Division of Endocrinology, Emory University School of Medicine, Atlanta, GA, United States, ⁶Division of Vascular Surgery, Emory University School of Medicine, Atlanta, GA, United States, ⁷Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, United States, ⁸Radiology, Emory University, Atlanta, GA, United States, ⁹Department of Orthopedics, Emory University School of Medicine, Atlanta, GA, United States

Synopsis

Keywords: IVIM, IVIM, Diabetes, Diabetic Foot Ulcer

Motivation: Prior work suggests abnormal perfusion to be a risk factor for poor wound healing in patients with diabetic foot ulcers. IVIM imaging provides quantitative measures of muscular perfusion, but these parameters lack cross-platform validation.

Goal(s): To compare IVIM in the foot of DFU patients across two different sites and scanner models.

Approach: Multi b-value DWI of the foot was acquired at rest and fit using the biexponential and fractional Fickian IVIM models in patients with DFUs (n=12).

Results: Preliminary IVIM results show mixed differences between sites. Ongoing comparisons will be obtained from diabetic patients without ulcers and healthy controls.

Impact: IVIM imaging provides markers of microvascular properties associated with poor wound healing. We report initial comparisons of IVIM parameters in diabetic foot ulcer patients obtained using two different scanner configurations and DWI sequences.

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