Abstract #3917

Evaluation of diffusion MRI-based cytometry imagine based on Spearman's correlation analysis

Zongshu Wang¹, Fan Liu², Lei Wu³, Li Chen⁴, Sisi Li⁵, Haihua Bao³, Junzhong Xu^6,7,8, Hua Guo², and Diwei Shi⁹

¹Tanwei College, Tsinghua University, Beijing, China, ²Center for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China, ³Qinghai University Affiliated Hospital, Xining, China, ⁴Tsinghua Shenzhen International Graduate School, Tsinghua University, Beijing, China, ⁵MR Research Collaboration, Siemens Healthineers, Beijing, China, ⁶Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ⁷Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ⁸Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, United States, ⁹Center for Nano and Micro Mechanics, Department of Engineering Mechanics, Tsinghua University, Beijing, China

Synopsis

Keywords: Microstructure, Microstructure

Motivation: DMRI-based cytometry methods have emerged for in-vivo microstructural imaging, however, it is difficult to evaluate accuracy of fitted results in clinic due to lack of ground-truth.

Goal(s): To quantitative evaluate accuracy of results through correlation analysis.

Approach: IMPULSED fitting and Spearman’s correlation analysis on dMRI data from 90 patients with malignant breast cancer. numerical simulations

Results: Strong correlation metrics between IMPULSED-derived microstructural parameters and measured ADC values can be used to evaluate the accuracy of model fitting, such as the metric of ν_invs. ADC_PGSE , which is higher to indicate lower fitted errors.

Impact: Evaluation for accuracy of emerging dMRI-based cytometry methods is limited by the lack of ground-truth, such as pathologic staining results. This prospective study demonstrated clinical potential of evaluating accuracy of imaging results through correlation analysis in the absence of ground-truth.

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