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Abstract #3924

Olfactory bulb volume and cerebral connectivity of post-viral (COVID-19) smell loss patients: preliminary results of APOLLO trial

Rashed Sobhan1,2, Zhu Hui Yeap3, Sara Bengtsson4, Saber Sami4, Thomas Hummel5, and Carl Philpott3,6
1Medical School, University of East Anglia, Norwich, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 4University of East Anglia, Norwich, United Kingdom, 5Department of Otorhinolaryngology, Smell and Taste Clinic, Dresden, Germany, 6ENT Department, James Paget Hospital, Great Yarmouth, United Kingdom

Synopsis

Keywords: Infectious Disease, COVID-19, fMRI (resting state), Functional connectivity, Infectious disease, Structural connectivity.

Motivation: Post-infectious olfactory disfunction (PIOD) came into light after COVID-19 pandemic. Many survivors have either completely or partially lost their smell sense. We recently completed APOLLO trial, which explores the effectiveness of vitamin-A nasal drops in regaining olfaction for PIOD patients

Goal(s): To investigate into the primary outcome of APOLLO trial: olfactory bulb volume (OBV) and two secondary outcomes: structural and functional cerebral connectivity.

Approach: We investigated the inter-observer agreement for manual OB segmentation; also, explored difference in connectivity between anosmic and hyposmic brains.

Results: The inter-observer agreement was satisfactory; no differences were found in the cerebral connectivity of anosmic and hyposmic cohort.

Impact: Interim analysis results on baseline scans of APOLLO trial’s olfactory disorder patients indicate their suitability to be extended for entire cohort. This study establishes the basis for currently ongoing APOLLO analysis.

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