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Abstract #3933

Assessment of Brain Glymphatic Function in Neurosyphilis Patients Using DTI-ALPS

Jingjing Li1, Yifei Zhang2, Shuo Li1, Kaiyu Qin3, Ruming Xie1, Hui Chen1, and Enshan Feng4
1Radiology, Beijing Ditan Hospital, Capital Medical University, Beijing, China, 2GE Healthcare, Beijing, China, 3Neurology, Beijing Ditan Hospital, Capital Medical University, Beijing, China, 4Neurosurgery, Beijing Ditan Hospital, Capital Medical University, Beijing, China

Synopsis

Keywords: Infectious Disease, Dementia, Neurosyphilis

Motivation: Explore glymphatic function changes in neurosyphilis using DTI-ALPS.

Goal(s): Evaluate whether DTI-ALPS can reflect neurosyphilis-related neural damage and serve as an imaging biomarker to predict cognitive functions.

Approach: DTI data were collected from 18 asymptomatic neurosyphilis patients, 28 with general dementia, and 32 healthy controls. Glymphatic function changes were analyzed, along with correlations with syphilis titers and resting-state BOLD-CSF coupling.

Results: DTI-ALPS predicted cognitive levels, with asymptomatic patients showing higher index, suggesting a protective role. Correlations with syphilis titers indicate potential as an imaging biomarker. The negative correlation with BOLD-CSF coupling supports its validity in reflecting glymphatic function.

Impact: After Treponema pallidum infection, the brain glymphatic system plays an important role in early pathogen clearance. DTI-ALPS can serve as an imaging biomarker to reflect syphilis-induced damage to the brain glymphatic system.

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