Abstract #3941

Comparative Study of Corpus Callosum Volume and Myelin Indices (MPF, MWF, MTR, FA) across Mammals: Independent Variability and Evolution

Kentaro Nishigami¹, Hiroyuki Hamaguchi¹, Nina Patzke², Maho Kitagawa¹, and Tha Khin Khin³

¹Laboratory for Biomarker Imaging Science, Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, sapporo, Japan, ²Hokkaido university, Sapporo, Japan, sapporo, Japan, ³3Global Center for Biomedical Science and Engineering, Hokkaido University Faculty of Medicine, Sapporo, Japan, sapporo, Japan

Synopsis

Keywords: White Matter, Animals

Motivation: To explore the relationship between corpus callosum volume and myelin indices across species, contributing to evolutionary insights and diagnostic markers.

Goal(s): Assess correlations between corpus callosum volume and indices in various mammals.

Approach: TWe measured these metrics in postmortem brains from diverse species using 3T MRI. ROIs were set with MRIcron, and histograms were created in ImageJ.

Results: Findings suggest corpus callosum volume and myelin metrics could act as independent markers, aiding neuroimaging and evolutionary studies.

Impact: These findings highlight that corpus callosum volume and myelin metrics can serve as independent markers in neuroimaging studies. This independence suggests distinct evolutionary paths for brain connectivity in different species,with implications for understanding neurological health and developing myelin-related diagnostic tools

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