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Abstract #3944

Arterial Spin Labeling MRI to Investigate Mineralocorticoid ReceptorAntagonism Effect on Brain Perfusion in the EAE Model

Mahir Rahman1, Mada Hashem1, Demitra Selimos1, Emily Wuerch1, Ying Wu1, Wee Yong1, and Jeff Dunn1
1University of Calgary, Calgary, AB, Canada

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis

Motivation: Prior research showed 40% of MS patients have cortical gray matter hypoxia, with similar findings in EAE mouse models linked to reduced cerebral blood flow.

Goal(s): To determine if the vascular-protective drug eplerenone can restore cerebral blood flow in the EAE mouse model of MS.

Approach: EAE was induced in mice receiving either 50mg/kg or 100mg/kg eplerenone. Cerebral blood flow was measured using continuous arterial spin labeling MRI at 9.4T.

Results: High dose eplerenone (100mg/kg) prevented reduction in cortical cerebral blood flow and improved clinical scores, while the lower dose showed no effects.

Impact: These findings suggest early treatment with mineralocorticoid receptor antagonists could prevent vascular dysfunction in MS patients, potentially avoiding cortical hypoxia. This introduces a new therapeutic approach targeting blood flow regulation rather than traditional immunomodulation strategies.

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