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Abstract #3948

Oligomeric amyloid-β targeted contrast agent for MRI in Mouse Models of Alzheimer's disease

Geon-Ho Jahng1, Jang Woo Park2, Yunan Tian3, Chanwoo Park 2, Hye Kyung Chung 2, and Kyeong Min Kim 2
1Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, 2Korea Radioisotope Center for Pharmaceuticals, Korea Institute of Radiological and Medical Sciences, Seoul, Korea, Republic of, 3Medicine, Graduate School, Kyung Hee University College of Medicine, Seoul, Korea, Republic of

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: Developing imaging tools for these hallmarks is important for the diagnosis and treatment of Alzheimer’s disease (AD).

Goal(s): To evaluate MRI signal changes in different mouse models and the time-dependent signal changes using our novel gadolinium (Gd)-dodecane tetraacetic acid (DOTA)- ob5 aptamer contrast agent.

Approach: We developed an MRI contrast agent by conjugating Gd-DOTA-DNA aptamer called ob5. A total of 10 control mice, 9 3xTg AD mice, and 11 APP/PS/Tau AD mice were included in this study.

Results: The signal enhancement peaked around 15 to 20 minutes after injection of the contrast agent.

Impact: Our novel contrast agent targeting oAβ has the potential ability to diagnose early AD and monitor the progression of AD.

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