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Abstract #3950

R2* Mapping in a Primate Model of CAA Shows Aging-Related Increases in GM and Reversal in WM with Transient Edema

Youssef Zaim Wadghiri1, Jakub Szabo2, Suleiman Khan2, Muhammad T Soliman2, Sean Murray2, Charles Kingsley3, Stanton Gray3, Jody Swain3, William D Hopkins3, Jelle Veerart2, Thomas Wisniewski2,4, and Henrieta Scholtzova2
1Radiology, NYU Grossman School of Medicine, NEW YORK, NY, United States, 2NYU Grossman School of Medicine, NEW YORK, NY, United States, 3MD Anderson Cancer Center, Houston, TX, United States, 4New York University Alzheimer's Disease Research Center, New York, NY, United States

Synopsis

Keywords: Alzheimer's Disease, Aging, quantitative mapping, white matter hyperintensities, CAA

Motivation: Amyloid-related imaging abnormalities (ARIA), seen in Alzheimer’s patients (AD) undergoing anti-amyloid immunotherapy, are partly caused by cerebral amyloid angiopathy (CAA). Squirrel monkeys (SQMs) offer a unique model for studying ARIA

Goal(s): Characterize MR imaging biomarkers in aging SQMs using conventional MRI for edema and quantitative R2* for iron-related pathology.

Approach: R2* map enables co-registration between animals allowing quantitative assessment via atlas-based analysis

Results: Whole brain R2* increase is mirrored in gray matter (GM) but not in white matter (WM). WM R2* reversal is likely due to edema, predominantly in the occipital and prefrontal cortex. Longitudinal monitoring revealed that WM hyperintensities can be transient.

Impact: ARIA is a condition seen during the pharmaceutical treatment of AD. Studying SQM can offer valuable insights into the disease mechanisms.

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