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Abstract #4019

Co-electrospun Axon-Mimicking Phantoms with Iron Oxide for Multimodal MRI

Fenglei Zhou1,2, Qi Li2, Longji Xu3, and Fei Gao3
1MicroPhantoms Ltd, Cambridge, United Kingdom, 2Qingdao University, Qingdao, China, 3Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

Synopsis

Keywords: Microstructure, Phantoms, Axon, T2 Mapping,T2* Mapping

Motivation: Validating MRI techniques for neurological disorders with iron accumulation requires phantoms that accurately mimic both iron concentration and neural microstructure.

Goal(s): Develop an axon-mimicking phantom with Fe3O4 to simulate iron deposition effects on DTI and T2/T2* mapping.

Approach: Co-electrospinning created polycaprolactone (PCL) microfibers with varying Fe3O4 concentration. Microstructure and stability were characterized. DTI and T2/T2* mapping were used to assess its ability to mimic iron's effects.

Results: The phantom, with excellent microstructure and properties, showed significant alterations in DTI metrics with increasing Fe3O4, consistent with neurodegenerative diseases. T2 and T2* mapping successfully simulated iron's magnetic susceptibility effects.

Impact: This phantom offers a robust platform for validating DTI and T2/T2* MRI in iron-related neurological disorders. It enables realistic assessment of MRI methods, their sensitivity to pathological changes, and potential for improving disease diagnosis and monitoring.

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