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Abstract #4025

Assessing Exosome Therapy Efficacy in Myocardial Infarction with Manganese-Enhanced MRI in a Porcine Model

Hiroyuki Takashima1,2, Eileen Tzng1, Gentaro Ikeda1, Nathan Bayardo1, Connor O’Brien3, Yuka Matsuura1, and Phillip C. Yang1
1Division of Cardiovascular Medicine, Stanford University, Palo Alto, CA, United States, 2Division of Biomedical Science and Engineering, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan, 3Division of Cardiovascular Medicine, University of California, San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Myocardium, large animals, nonhuman primates

Motivation: Effective imaging methods are needed to assess the mechanisms of exosome therapy in myocardial infarction (MI) recovery.

Goal(s): This study aimed to compare delayed-enhancement MRI (DEMRI) and manganese-enhanced MRI (MEMRI) in evaluating the therapeutic effects of iCM- and MSC-derived exosomes on cardiac function.

Approach: Yorkshire swine underwent LAD occlusion and reperfusion, followed by injections of PBS (control) or exosomes into the peri-infarct region. Cardiac function and viability were measured via DEMRI and MEMRI.

Results: MEMRI captured significant viability improvements with exosome therapy, highlighting its potential as a superior modality for assessing cardiac recovery mechanisms.

Impact: This study demonstrates MEMRI’s potential as a superior imaging modality for assessing exosome therapy efficacy in myocardial infarction, providing insights into regenerative mechanisms and highlighting the therapeutic promise of iCM- and MSC-derived exosomes in cardiac therapeutics.

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Keywords