Abstract #4028

Relationship Between Fractional Myocardial Blood Volume and T1 Reactivity using Ferumoxytol-Enhanced Cardiovascular Magnetic Resonance

Arutyun Pogosyan^1,2, Mostafa Mahmoudi^1,2, Xinyu Dong¹, Zhengyang Ming^3,4, Yuxin Li⁵, J. Paul Finn^3,4, and Kim-Lien Nguyen^1,2,3,4

¹Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ²Division of Cardiology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States, ³Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ⁴Physics and Biology in Medicine Graduate Program, University of California Los Angeles, Los Angeles, CA, United States, ⁵Nuclear Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States

Synopsis

Keywords: Perfusion, Perfusion, Ischemia, Myocardium, Myocardial Blood Volume, Ferumoxytol, T1 Reactivity

Motivation: Fractional myocardial blood volume (fMBV) and T1 reactivity derived from magnetic resonance imaging have emerged as promising biomarkers for assessing tissue perfusion. Ferumoxytol, an off-label intravascular MRI contrast agent, enhances the dynamic range of T1 reactivity and enables fMBV computation using a two-compartment water exchange model.

Goal(s): This study seeks to evaluate the relationship between fMBV and T1 reactivity.

Approach: Ten participants underwent T1 mapping with ferumoxytol-enhanced cardiac magnetic resonance (FE-CMR) at both rest and regadenoson-induced stress.

Results: Our results reveal an inverse relationship between fMBV and T1 reactivity in healthy volunteers undergoing stress FE-CMR.

Impact: Our findings demonstrate the distribution of ferumoxytol-enhanced fractional myocardial blood volume and its relationship with T1 reactivity. If validated, these biomarkers could offer valuable insights into local tissue perfusion without requiring invasive procedures or gadolinium-based contrast agents.

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