Abstract #4031

Ultra-small iron oxide nanoparticles for diagnosing deep vein thrombosis in T1-weighted magnetic resonance imaging

Tianming Cui¹, Yun Xu², Yong Zhang³, Peijun Wang², Weitao Yang⁴, and Bingbo Zhang⁴

¹Shanghai research institute for intelligent autonomous systems, Tongji University, Shanghai, China, ²Department of Radiology, Tongji Hospital of Tongji University, Shanghai, China, ³MR Research, GE Healthcare, Shanghai, China, ⁴Department of Radiology, Tongji Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, China

Synopsis

Keywords: Hematology, Oncology, Vascular, Venous thrombosis

Motivation: Deep vein thrombosis (DVT) has been one of the leading causes of sudden death. However, the lack of clinically available venous-specific magnetic resonance contrast agents makes it difficult to diagnose.

Goal(s): Design and synthesis of a vein-specific magnetic resonance contrast agent for deep vein thrombosis imaging has become an urgent clinical need.

Approach: In this study, we synthesized a novel type of ultra-small iron oxide nanoparticles, utilizing the property of nanoparticles being difficult to extravasate to achieve resonance imaging of venous vessels.

Results: The results demonstrate that ultra-small iron oxide can diagnose deep venous thrombosis of the lower extremities.

Impact: Ultra-small iron oxide improves clinical deep vein thrombosis detection, addressing venous contrast agent deficiencies and advancing MRI use in clinical settings.

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