Keywords: Diffusion Modeling, Diffusion Modeling, Spinal cord, brain, diffusion models, free water, NODDI, SMT, SMI
Motivation: Multiple sclerosis (MS) is a neurodegenerative disease with gaps in brain and spinal cord (SC) imaging necessitating advanced diffusion techniques to capture MS pathology.
Goal(s): We sought to quantify axonal loss and understand the sensitivity of volume fraction measures to characterize MS microstructural changes.
Approach: We comprehensively imaged the brain and cervical SC and applied measures from diffusion models in gray matter (GM), white matter (WM), and lesions in patients with relapsing-remitting MS (pwRRMS) and healthy controls (HCs).
Results: We reveal significantly reduced volume fraction indices in MS lesions compared to HC WM and significant correlations between pwRRMS lesion indices and lesion volume.
Impact: Volume fraction measures from novel diffusion models are sensitive to disease pathology in brain and spinal cord lesions of patients with multiple sclerosis, providing evidence of the utility of specific diffusion measures to capture axonal loss.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords