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Abstract #4036

Predicting Mesoscopic Larmor Frequency Shifts in White Matter with Diffusion MRI - A Monte-Carlo Study in Axonal Phantoms

Anders Dyhr Sandgaard1 and Sune Nørhøj Jespersen1,2
1Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 2Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Synopsis

Keywords: Simulation/Validation, Simulation/Validation

Motivation: Axonal magnetic microstructure causes an anisotropic mesoscopic Larmor frequency shift in MRI that depends on each axon’s direction relative to the B0 field. This shift is modeled in µQSM

Goal(s): This study aims to validate µQSM's ability to predict mesoscopic Larmor frequency shifts using diffusion MRI (dMRI) data from realistic white matter axons.

Approach: Monte-Carlo simulations in the intra-axonal space of mesoscale in-silico white matter axonal phantoms were performed to test whether fiber orientation distributions estimated from diffusion MRI can predict the anisotropic mesoscopic Larmor frequency shift induced by the axons.

Results: dMRI successfully predicts mesoscopic Larmor frequency from in-silico white matter microstructure.

Impact: µQSM may improve estimation of tissue magnetic susceptibility and lead to susceptibility imaging with higher diagnostic value.

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Keywords