Keywords: Simulation/Validation, Simulation/Validation
Motivation: Axonal magnetic microstructure causes an anisotropic mesoscopic Larmor frequency shift in MRI that depends on each axon’s direction relative to the B0 field. This shift is modeled in µQSM
Goal(s): This study aims to validate µQSM's ability to predict mesoscopic Larmor frequency shifts using diffusion MRI (dMRI) data from realistic white matter axons.
Approach: Monte-Carlo simulations in the intra-axonal space of mesoscale in-silico white matter axonal phantoms were performed to test whether fiber orientation distributions estimated from diffusion MRI can predict the anisotropic mesoscopic Larmor frequency shift induced by the axons.
Results: dMRI successfully predicts mesoscopic Larmor frequency from in-silico white matter microstructure.
Impact: µQSM may improve estimation of tissue magnetic susceptibility and lead to susceptibility imaging with higher diagnostic value.
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