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Abstract #4042

Histologically Informed Periodic Axon Substrate Generator for Time-Dependent Diffusion MRI

TuanKhai Nguyen1,2, Mark D Does1,2,3, and Kevin D Harkins1,2,3
1Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 3Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Simulation/Validation, Phantoms, Brain, Spinal cord, White matter, Microstructure

Motivation: Existing methods for constructing white matter numerical substrates suffer from geometric discontinuities at substrate boundaries.

Goal(s): Develop a framework for realistic white matter substrates for diffusion MRI simulations that capture microstructure continuity across substrate boundaries.

Approach: This study introduces a novel framework for ensuring microstructure continuity across boundaries by periodically adding reciprocal axons for items that cross or close to boundaries during substrate generation.

Results: The method successfully constructs complex, biomimetic white matter substrates with geometric continuities in 3D, while achieving high packing densities (~74%) and controlled diameter distribution, orientation dispersion, and beading.

Impact: The framework developed can facilitate more accurate Monte Carlo simulations without confounding effects of boundary artifacts for investigating microstructural contributions to diffusion MRI.

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Keywords