Abstract #4046

Histology Validation of Generalized Diffusion Basis Spectrum Imaging in Postmortem Alzheimer Disease Brain

Meng Jiang^1,2, Wenjie Wu², Yuan Nan³, Aakash Patel¹, Erin E. Franklin⁴, Richard J. Perrin⁴, Tammie L.S. Benzinger¹, Yong Wang^1,3,5,6, and Qing Wang^1,5,6

¹Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, United States, ²Department of Obstetrics & Gynecology, Washington University School of Medicine, Saint Louis, MO, United States, ³Department of Electrical & Systems Engineering, Washington University in St. Louis, Saint Louis, MO, United States, ⁴Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, United States, ⁵Department of Mechanical Engineering & Materials Science, Washington University in St. Louis, Saint Louis, MO, United States, ⁶Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, United States

Synopsis

Keywords: Diffusion Modeling, Diffusion Modeling

Motivation: Alzheimer disease pathology often begins in cortical gray matter, a non-invasive method for visualizing AD-related changes in gray matter is needed.

Goal(s): Validate Generalized Diffusion Basis Spectrum Imaging (g-DBSI) as a tool for detecting microstructural components in both white and gray matter in postmortem AD brain tissues.

Approach: We compared g-DBSI-derived maps with histology-based density maps using postmortem AD brain tissue samples to assess correlation and accuracy in capturing microstructural details.

Results: Significant correlations were found between g-DBSI indices and histological density maps, supporting g-DBSI’s effectiveness in representing cell nucleus and axon densities in gray matter and white matter in postmortem AD brain.

Impact: g-DBSI could enable earlier, non-invasive monitoring of AD progression, offering a valuable tool for studying neuroinflammation and cellular changes directly in gray matter.

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