Abstract #4052

Physiological mechanism of water exchange across the blood-brain barrier

Zejun Wang¹, Songtao Hu¹, Yaou Liu², and Ruiliang Bai³

¹Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ³Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, China

Synopsis

Keywords: Diffusion Analysis & Visualization, Animals, Water exchange across blood-brain barrier, Filter exchange imaging, Physiological mechanism

Motivation: Studies have shown MRI-measured water exchange across the blood-brain barrier (BBB) can serve as a sensitive biomarker for detecting subtle BBB disruptions. However, physiological mechanisms underlying this water exchange remain unclear.

Goal(s): To investigate physiological mechanisms driving water exchange across the BBB.

Approach: Vascular exchange imaging (VEXI) was used to measure water exchange across BBB in rats. Ouabain and TGN020 were administered to inhibit Na⁺, K⁺-ATPase and AQP4, respectively, to assess their individual contributions to this process.

Results: Water exchange across the BBB decreased by 30% after administration of ouabain, but didn’t show downward trend after administration of TGN020.

Impact: This study advances the understanding of physiological mechanisms regulating water exchange across the BBB and offers a fundamental reference for future research on this topic.

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