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Abstract #4058

Innovative Tissue Perfusion Views:Using Diffusion-Derived Vessel Density Habitat Analysis for Isocitrate Dehydrogenase Genotyping in Glioma

Chenxi Ni1, Ruolan Lin1, Hongdan Guan1, Yang Song2, Guang Yang3, and Rifeng Jiang1
1Fujian Medical University Union Hospital, Fuzhou, China, 2Siemens Healthineers Ltd, Shanghai, China, 3East China Normal University, Shanghai, China

Synopsis

Keywords: Diffusion Analysis & Visualization, Diffusion Analysis and Visualization

Motivation: The goal of study is to improve glioma classification by non-invasively evaluating IDH genotypes through the use of DDVD and habitat analysis. This study emphasizes the examination of tissue perfusion within the tumor microenvironment.

Goal(s): Distinguishing IDH genotypes of diffuse gliomas by applying DDVD analysis across the entire tumor parenchyma and its specific habitats.

Approach: This study employs DWI to collect DDVD metrics from 63 patients diagnosed with gliomas. The DDVD metrics were correlated with IDH genotypes and Ki-67 status.

Results: Significant differences in DDVD were observed between IDH-mutant and IDH-wildtype gliomas. The habitat analysis notably enhanced the diagnostic performance for IDH genotyping.

Impact: This study introduces DDVD as a novel biomarker for non-invasive IDH genotyping in diffuse gliomas, offering valuable insights into tumor biology and advancing the field toward more personalized treatment strategies in neuro-oncology.

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