Keywords: Diffusion Analysis & Visualization, DWI/DTI/DKI, ALPS
Motivation: Reducing the dependence of ALPS on manual region selection, head and fibre orientation.
Goal(s): Robust and automated ROI placement and ALPS-index calculation on acquired data.
Approach: Development of a workflow for automatic ROI placement in DWI space, validated with in vivo measurements under varied head rotations. ALPS-index values using the principal axis system (PAS) and the laboratory frame were compared across MNI and DWI spaces.
Results: Both methods yielded ROIs in anatomically meaningful places and corrected for head rotation. In addition, ALPS-PAS accounted for fibre orientation, did not require data registration and yielded higher indices.
Impact: Accurate, automated placement of ROIs for ALPS-PAS yields a stronger ALPS effect and reproducible ROIs without registration of the acquired data, ideal for longitudinal studies.
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