Keywords: Diffusion Acquisition, Acquisition Methods
Motivation: Diffusion-weighted MRS (dMRS) generates field fluctuations that distort spectral line shapes. Traditional water reference scans can be noisy at high b-values and fail to correct the spectra.
Goal(s): This study aims to (1) map field fluctuations, (2) develop a stable phantom reference, (3) validate it against water scans in high-b-value acquisitions, and (4) extract diffusion properties.
Approach: Spatial field fluctuations were mapped with a high-viscosity silicone oil phantom, and its performance in phase correction was compared to water reference scans in simulations and invivo.
Results: The phantom reference was used to successfully correct invivo dMRS data up to a b-value of 37 ms/µm².
Impact: This research can help improve dMRS data quality at high b-values by correcting signal distortions with a phantom reference scan. This reduces scanning time in human studies and makes dMRS more practical for clinical use.
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