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Abstract #4076

Correction of time-dependent phase fluctuations in diffusion-weighted MRS at high b-values with external phantom reference

Kristin Engel1,2, Vanessa Wiggermann1, Itamar Ronen3, and Henrik Lundell1,2
1Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark, 2Magnetic Resonance Section, DTU Health Tech, Technical University of Denmark, Kongens Lyngby, Denmark, 3Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom

Synopsis

Keywords: Diffusion Acquisition, Acquisition Methods

Motivation: Diffusion-weighted MRS (dMRS) generates field fluctuations that distort spectral line shapes. Traditional water reference scans can be noisy at high b-values and fail to correct the spectra.

Goal(s): This study aims to (1) map field fluctuations, (2) develop a stable phantom reference, (3) validate it against water scans in high-b-value acquisitions, and (4) extract diffusion properties.

Approach: Spatial field fluctuations were mapped with a high-viscosity silicone oil phantom, and its performance in phase correction was compared to water reference scans in simulations and invivo.

Results: The phantom reference was used to successfully correct invivo dMRS data up to a b-value of 37 ms/µm².

Impact: This research can help improve dMRS data quality at high b-values by correcting signal distortions with a phantom reference scan. This reduces scanning time in human studies and makes dMRS more practical for clinical use.

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