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Abstract #4079

Diffusion MRI model of optic nerve microstructure in glaucoma patients

Patryk Filipiak1,2, Lucas Ma1,2,3, Vaidehi S. Dedania4, Kevin C. Chan1,4,5, and Steven H. Baete1,2
1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, NYU Langone Health, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, NYU Langone Health, New York, NY, United States, 3Herricks High School, New Hyde Park, NY, United States, 4Department of Ophthalmology, NYU Langone Health, New York, NY, United States, 5Neuroscience Institute and Tech4Health Institute, NYU Langone Health, New York, NY, United States

Synopsis

Keywords: Microstructure, Neurodegeneration, glaucoma, CSF flow, microstructure modeling

Motivation: Clinically available methods fail to identify pathophysiological microstructure changes occurring along the optic nerve in glaucoma.

Goal(s): We aim to quantify optic neuropathy and CSF flow along the optic nerve with diffusion MRI to advance understanding of the disease mechanism and support early diagnosis.

Approach: Our study proposes a dedicated microstructure model and a ROI sampling scheme to evaluate glaucomatous changes in the human optic nerve.

Results: The proposed model correctly identifies optic nerve degeneration and impeded CSF flow in glaucoma patients based on clinically feasible diffusion MRI.

Impact: Vision loss due to glaucoma is preventable if diagnosed early. Our approach has the potential to identify glaucomatous changes in patients undergoing diffusion MRI exam and thus support timely and targeted treatment.

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