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Abstract #4084

Fixel-wise reductions of thalamic fiber integrity in new onset epilepsy and drug-resistant temporal lobe epilepsy

Lucas E Sainburg1,2, Kaiser Williams1, Derek J Doss1,2, Kurt G Schilling2, Dario J Englot1,2,3, and Victoria L Morgan1,2,3
1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 3Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Epilepsy, Epilepsy

Motivation: Axonal changes that occur throughout epileptogenesis and early-stage epilepsy remain unclear.

Goal(s): We aimed to identify and relate diffusion weighted MRI changes in the thalamus of patients with new onset epilepsy and patients with long term drug-resistant temporal lobe epilepsy.

Approach: We compared diffusion MRI at different orientations within each voxel (fixels) in the thalamus of patients with new onset epilepsy, temporal lobe epilepsy, and healthy controls.

Results: We found that patients with new onset epilepsy trended towards reductions in fiber integrity of the right ventral thalamus, similar to those of patients with drug-resistant temporal lobe epilepsy.

Impact: Our results suggest that ventral thalamus fibers may be damaged in temporal lobe epilepsy and this damage could be detectable in early-stage epilepsy. These results may have implications for thalamic neurostimulation and future studies of progression in new onset epilepsy.

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