Keywords: Epilepsy, Epilepsy
Motivation: Axonal changes that occur throughout epileptogenesis and early-stage epilepsy remain unclear.
Goal(s): We aimed to identify and relate diffusion weighted MRI changes in the thalamus of patients with new onset epilepsy and patients with long term drug-resistant temporal lobe epilepsy.
Approach: We compared diffusion MRI at different orientations within each voxel (fixels) in the thalamus of patients with new onset epilepsy, temporal lobe epilepsy, and healthy controls.
Results: We found that patients with new onset epilepsy trended towards reductions in fiber integrity of the right ventral thalamus, similar to those of patients with drug-resistant temporal lobe epilepsy.
Impact: Our results suggest that ventral thalamus fibers may be damaged in temporal lobe epilepsy and this damage could be detectable in early-stage epilepsy. These results may have implications for thalamic neurostimulation and future studies of progression in new onset epilepsy.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords