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Abstract #4086

The Association of the Glymphatic Function with amyloid deposition: a clinical stage-specific Approach

Koung Mi Kang1, Hyeryeong Nam2, Chanrim Park2, Min Soo Byun3, Dahyun Yi4, Chul-Ho Sohn1, and Dong Young Lee3
1Radiology, Seoul National University Hospital, Seoul, Korea, Republic of, 2Seoul National University Hospital Biomedical Research Institute, Seoul, Korea, Republic of, 3Neuropsychiatry, Seoul National University Hospital, Seoul, Korea, Republic of, 4Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: Glymphatic dysfunction may contribute to Alzheimer’s pathology by impairing the clearance of amyloid β, leading to its accumulation.

Goal(s): This study aims to investigate whether the ALPS index, a DTI-based measure of glymphatic function, correlates with amyloid β deposition.

Approach: ALPS index values and amyloid β deposits were examined in cognitively normal and impaired older adults, with adjustments for age, sex, APOE ε4 status, and white natter hyperintensity volume.

Results: The ALPS index was significantly lower in cognitively impaired group and inversely correlated with amyloid β deposition in the cognitively normal group.

Impact: These findings suggest the ALPS index as a potential early biomarker for Alzheimer’s, highlighting glymphatic dysfunction’s role.

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