Keywords: Dementia, Neurodegeneration, Diffusion Tensor Imaging, Neurite Orientation Dispersion and Density Imaging, TAR DNA binding protein 43, LATE-NC
Motivation: TDP-43 deposition in Alzheimer's disease (AD) is associated with atrophy of the temporal lobe, yet diffusion changes in AD-related TDP-43 proteinopathy are understudied.
Goal(s): Evaluate the utility of diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) as in-vivo markers for detecting AD-related TDP-43 proteinopathy.
Approach: A cross-sectional analysis of temporal lobe DTI and NODDI metrics was conducted in 49 autopsy-confirmed AD cases, comparing TDP-43-positive cases to negative cases.
Results: TDP-43-positive cases showed greater diffusion abnormalities in the left hippocampus, amygdala, and uncinate fasciculus, suggesting these metrics can aid in detecting AD-related TDP-43 pathology.
Impact: The study demonstrates that TDP-43 significantly affects brain microstructure in AD, particularly in the left temporal lobe, with diffusion changes from DTI and NODDI potentially serving as biomarkers for early detection and diagnosis of TDP-43 in AD.
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