Keywords: Aging, Aging, Gray matter
Motivation: Brainstem nuclei are understudied in brain development/aging due to typically low spatial resolution of diffusion MRI.
Goal(s): To investigate micro-structural changes with age/sex in red nucleus and substantia nigra across the lifespan.
Approach: Diffusion tensor imaging was acquired with 1 mm³ voxels to assess age trajectories in 193 healthy controls (5-83 years; 105 females).
Results: Diffusion metrics had non-linear age trajectories that differed from volume and susceptibility. For both nuclei, mean diffusivity showed a quadratic age trajectory (minima ~50 years) with similar values between males and females in children, but became divergent at older ages (females higher).
Impact: High-resolution diffusion MRI of brainstem nuclei indicated marked non-linear changes with age across the typical lifespan that differed with sex. This establishes a baseline for investigation of micro-structural alterations of the red nucleus and substantia nigra in neurological disorders.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords