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Abstract #4095

Coupling analysis of MRI-detected impaired glymphatic system with abnormal cerebral blood flow in methamphetamine-dependent patients

Ping Cheng1, Yadi Li1, Qingqing Wen2, Liang Liang1, and Wenhua Zhou3
1Department of Radiology, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, China, ningbo, China, 2GE HealthCare MR Research, Beijing, China, Beijing, China, 3Department of Academic Research, Ningbo Kangning Hospital, Ningbo University, Ningbo, China, Key Laboratory of Addiction Research of Zhejiang Province, Ningbo, China, Ningbo, China

Synopsis

Keywords: Psychiatric Disorders, Nervous system

Motivation: The use of non-invasive MRI research methods to explore the function of the cerebral glymphatic system in methamphetamine (MA)-dependent patients has been limited.

Goal(s): Investigating the function of the glymphatic system and its coupling with cerebral blood flow (CBF) in MA-dependent individuals using diffusion tensor imaging (DTI) and arterial spin labeling (ASL).

Approach: The diffusion coefficients of the projection and associated fiber, DTI along the perivascular space (DTI-ALPS) index, and CBF were calculated and compared between MA-dependent and normal individuals.

Results: Patients with MA dependence exhibit decreased DTI-ALPS index. A significant positive correlation has been observed between DTI-ALPS and CBF in MA-dependent individuals.

Impact: DTI-ALPS showed the potential to emerge as a novel imaging biomarker for MA dependence. Furthermore, the strong coupling between the ALPS and CBF might contribute to understanding the changes of brain function in MA-dependent patients.

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