Abstract #4099

Multimodal MRI Reveals Neurobiological Alterations in High Schizotypy: Insights from Diffusion and Perfusion Imaging

Zhujun Wei^1,2, Wei Mao^1,2, Lixian Wang³, Yunru Wang^4,5, Xuan Wang^4,5, Yihang Huang^4,5, Lingling Wang⁶, Huixin Hu⁷, Fangrong Zong⁸, Yi Wang^4,5, Simon F. Eskildsen⁹, Raymond C.K. Chan^4,5, and Rong Xue^1,2,10

¹Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ²Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China, ³Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁴Neuropsychology and Applied Cognitive Neuroscience Laboratory; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China, ⁵Department of Psychology, University of Chinese Academy of Sciences, Beijing, China, ⁶School of Psychology, Shanghai Normal University, Shanghai, China, ⁷Department of Psychology, School of Humanities and Social Sciences, Beijing Forestry University, Beijing, China, ⁸School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China, ⁹Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ¹⁰Beijing Institute for Brain Disorders, Beijing, China

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders, Schizotypy, diffusion, perfusion, NODDI

Motivation: The etiology of schizophrenia still remains unclear that makes it harder to predict its progression.

Goal(s): This study aims to highlight early neurobiological markers associated with schizophrenia.

Approach: This study employed diffusion and perfusion weighted imaging to identify the structural and functional brain changes in high schizotypy population, individuals with subclinical manifestations of schizophrenia.

Results: Diffusion weighted imaging reveals significant white matter abnormalities specifically in right hemisphere. Perfusion imaging shows prolonged arterial transit time and reduced cerebral blood flow in few brain regions.

Impact: Our findings suggest early potential biomarkers of schizophrenia through multi-modal MRI, which is critical for early diagnosis and intervention strategies in high-risk populations.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.